Laga soo bilaabo bukaanka ilaa cilmi-baarista: Sahaminta saameynta probiotic-ka ee afar-xagal ee cudurka Parkinson

Fikradda tijaabadan waxay ku salaysan tahay iskaashi dhab ah oo bukaan-socod iyo dhakhtar. Sannadkii 2016, Jon Hiseman oo geeriyooday, oo ahaa durbaan garaace halyeey ah oo ka tirsanaa kooxda caanka ah ee jazz-rock ee Colosseum, ayaa nagala hadlay xaaskiisa, oo geeriyootay Barbara Thompson, oo qabta cudurka Parkinson (PD) oo horumarsan isla markaana nalagu hayay daryeelkeeda. Barbara lafteedu waxay ahayd saxophone caan ah iyo hoggaamiye Paraphernalia, waxayna ka soo muuqatay xafladdii furitaanka ee Golaha MDS ee Stockholm sannadkii 2014. Jon ayaa sheegay in Barbara ay la kulantay horumar la taaban karo oo ku yimid saameynta levodopa iyo fayoobaanteeda guud ka dib markii ay qaadatay probiotic afar-xagal ah oo ay ku jiraan Lactobacillus acidophilus, Lactiplantibacillus plantarum, Lacticaseibacillus rhamnosus, iyo Enterococcus faecium. Aragtidan ayaa naga dhigtay inaan dib u eegno caddaymaha soo baxaya ee ku saabsan microbiota mindhicirka iyo probiotics ee PD [1] iyo inaan raadino maalgelin tijaabo caafimaad oo la xakameeyey, ka dib daraasad guul leh oo ka horreysay kiliinikada oo la sameeyay iyadoo lala kaashanayo Jaamacadda College London [2].

Cilladda caloosha iyo isbeddellada bararka ee microbiota mindhicirka ayaa si isa soo taraysa loogu aqoonsaday inay yihiin astaamo muhiim u ah PD, oo ku fidsan dhammaan marxaladaha xaaladda, laga bilaabo prodromal ilaa cudur horumarsan [3,4]. Male-awaalka ugu muhiimsan ee mashruucan wuxuu ahaa in cilladda caloosha iyo mindhicirka, oo ay weheliso calaamadaha kale ee dhaqdhaqaaqa iyo kuwa aan dhaqdhaqaaqa ahayn (NMS), ay saameyn ku yeelan karaan microbiota mindhicirka sidaas darteedna qayb ahaan wax looga qaban karo iyada oo loo marayo waxqabadyada wax ka beddelaya mindhicirka sida probiotics. In kasta oo probiotics-ka horey loogu tixgeliyey ikhtiyaar daaweyn oo waxtar leh oo loogu talagalay calool istaagga PD [3] oo lagu ansixiyay warqadda caafimaadka ee PD [5], farsamooyinka salka ku haya faa'iidooyinkooda ballaaran ee suurtagalka ah weli ma cadda.

Waxaan naqshadeynay oo aan sameynay tijaabo xakameyn badan oo xudunta ah, oo aan kala sooc lahayn, oo indho la'aan ah, oo placebo-xakameysan oo ka dhacday Isbitaalka King's College iyo King's College London (UK), iyadoo lala kaashanayo Isbitaalka Jaamacadda Skåne, Lund (Sweden). Toddobaatan iyo afar bukaan oo qaba PD iyo calool istaag ayaa si aan kala sooc lahayn loo kala saaray si loogu qaato probiotic-ka afar-xagal ama placebo afka muddo 12 toddobaad ah. Cabbirka natiijada ugu weyn wuxuu ahaa tirada kala duwan ee microbiota taxa ee mindhicirka u dhexeeya bilowga iyo usbuuca 12 ee kooxaha firfircoon iyo placebo. Natiijooyinka labaad waxaa ka mid ahaa isbeddellada heerarka plasma ee cytokines bararka. Natiijooyinka sahaminta waxay ka koobnaayeen isbeddellada ku yimid plasma iyo asiidhyada dufanka gaaban ee silsiladda saxarada (SCFAs), iyo sidoo kale cabbirrada mootada iyo NMS.

Waxaan aragnay kobcinta bakteeriyada taxa oo leh sifooyin la aqoonsan yahay oo la xiriira caafimaadka (oo ay ku jiraan Odoribacteraceae, Enterococcaceae, iyo Blautia faecicola) kooxda firfircoon marka la barbar dhigo placebo. Intaa waxaa dheer, heerarka balaasmaha ee cytokine-ka pro-bararka TNF-α ayaa hoos u dhacay ka dib daaweynta probiotic. Isbeddello muhiim ah laguma arag heerarka SCFA. Caafimaad ahaan, hoos u dhac ku yimid waqtiga-ilaa-ka-dib maamulka levodopa iyo guud ahaan culeyska NMS - oo ay ugu horreyn horseedday horumarinta calool istaagga iyo daalka - ayaa lagu arkay kooxda firfircoon.

Natiijooyinka tijaabada SymPD waxay soo jeedinayaan in probiotic-kan afar-xagal ah uu si faa'iido leh u beddeli karo microbiota mindhicirka, iyadoo leh saameyn hoos u dhac ah oo ku iman karta bararka nidaamka, waqtiga jawaabta levodopa, iyo culeyska calaamadaha aan dhaqdhaqaaqa lahayn ee bukaanada qaba PD iyo calool istaagga. Natiijooyinkani waxay taageeraan baaritaan dheeraad ah oo ku saabsan probiotics-ka oo ah istaraatiijiyad cusub oo daaweyn ah oo loogu talagalay cudurka Parkinson.

tixraacyada

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